NSAIDs : Mnemonics


Mnemonic: Prescribed By SOFIA

  1. Propionic acid derivatives: Ibuprofen, Ketoprofen, Flurbiprofen, Naproxen
  2. Pyrrolo-pyrrole derivates: Ketoroloac
  3. Pyrazolone derivatives: Phenylbutazone, Oxybutazone
  4. Benzoxazocine derivatives: Nefopam
  5. Salicyaltes: Aspirin
  6. Selective COX-2 inhibitor: Celecoxib, Etoricoxib, Parecoxib
  7. Oxicam derivatives: Piroxicam, Tenoxicam
  8. Fenamic acid derivatives: Mefenamic acid (Anthranilic acid derivative)
  9. Indol derivatives: Indomethacin, Sulindac
  10. Aryl acetic acid derivatives: Diclofenac, Aceclofenac
nsaid classification

Side effects and Contraindications

Mnemonic: BARS

  1. Bleeding
    • Inhibit platelet cycloxygenase (COX), thereby blocking the formation of thromboxane A2 (TXA2) and impairing TXA2 dependent platelet aggregation
  2. Asthma
    • Inhibition of COX pathway shifts the arachidonic acid metabolism to Lipoxygenase (LOX) pathway leading to increased leukotriene synthesis
  3. Allergy
    • Upto 2% prevalence
  4. Renal disease
    • Inhibition of PGE2/PGI2 leads to constriction of afferent arteriole and pre-renal AKI
    • Leads to sodium retention (peripheral edema, hypertension, heart failure)
  5. Stomach: Mucosal damage by –
    • COX-1 inhibition: Reduced blood flow
    • Topical irritation: Epithelial damage
    • COX-2 inhibition: Leukocyte adherence

Beneficial effects

Mnemonic: Five “A”s

  1. Analgesic
  2. Antipyretic
  3. Anti-inflammatory
  4. Anti-thrombotic
  5. Arteriosus closure (PDA closure)

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