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Pharmacology

PGMEE, MBBS, MD/MS

Methotrexate : Mnemonic

Epomedicine Feb 21, 2023 No Comments Pharmacology

Methotrexate is a dihydrofolate reductase (DHFRase) inhibitor which inhibits DNA repair, synthesis and cellular replication. Actively proliferating tissues such as malignant cells, bone marrow, fetal…

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PGMEE, MBBS, MD/MS

Ketamine : Mnemonic

Epomedicine Feb 11, 2023 No Comments AnesthesiaEmergency medicinePharmacology

K: Kids (Induction agent of choice in children) E: Emergence reaction (floating sensations, vivid dreams and hallucination; reduced using benzodiazepines), Enantiomers (S-Ketamine and R-Ketamine) T:…

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PGMEE, MBBS, MD/MS

Pharmacology of Clindamycin : Mnemonic

Epomedicine Aug 13, 2022 No Comments Pharmacology

Class: Lincosamide Mechanism of action: Binds 50S subunit of ribosome and inhibits translation – bacteriostatic (Remember the mnemonic: buy AT 30 & CELLS at 50)…

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PGMEE, MBBS, MD/MS

NSAIDs : Mnemonics

Epomedicine Jul 28, 2022 No Comments Pharmacology

Classification Mnemonic: Prescribed By SOFIA Propionic acid derivatives: Ibuprofen, Ketoprofen, Flurbiprofen, Naproxen Pyrrolo-pyrrole derivates: Ketoroloac Pyrazolone derivatives: Phenylbutazone, Oxybutazone Benzoxazocine derivatives: Nefopam Salicyaltes: Aspirin Selective…

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PGMEE, MBBS, MD/MS

Management of Anti-tubercular therapy (ATT) induced Hepatitis

Epomedicine May 21, 2022 No Comments Infectious diseaseInternal medicinePediatricsPharmacology

Definition of ATT induced hepatitis ALT > 3 X Normal + Symptoms OR ALT > 5 X Normal without Symptoms Management of ATT induced hepatitis…

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PGMEE, MBBS, MD/MS

Pregabalin vs Gabapentin

Epomedicine May 10, 2022 No Comments Nervous systemPharmacology

Both pregabalin and gabapentin are GABA analogues that bind to presynaptic neuron’s voltage-gated calcium channels (VGCC), specifically to the alpha-2-delta protein leading to reduced calcium…

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PGMEE, MBBS, MD/MS

Atropine Induced Paradoxical Bradycardia

Epomedicine Jan 5, 2022 No Comments AnesthesiaInternal medicinePediatricsPharmacology

Atropine induced paradoxical bradycardia is the sinus bradyarrhythmia following low-dose atropine resulting from the paradoxical slowing in the sinoatrial (SA) node discharge rate. Mechanism of…

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PGMEE, MBBS, MD/MS

Pregabalin : Pharmacology

Dr. Henrique Durão Dec 5, 2021 No Comments Internal medicinePharmacology

Pharmacokinetics After oral ingestion, Pregabalin is rapidly absorbed (Tmax 1.3 hr) Bioavailability is >90% and independent of dose Pregabalin is NOT protein bound Vd is…

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