Antidepressants Made Easy

Tricyclic Antidepressants (TCA) Mnemonic: -pramine, -triptyline, -pin Secondary amines: predominantly norepinephrine reuptake inhibitors Nor-triptyline Desi-pramine Tertiary amines: Ami-triptyline Imi-pramine Clomi-pramine Doxe-pin Irreversible MAO Inhibitors Mnemonic: TIPS Non-selective MAO inhibitors: Tranylcypromine Isocarboxazid Phenelzine Selective MAO-B inhibitor: Selegiline (transdermal patch) Reversible Inhibitor of MAO-A (RIMA) Moclobemide Tolaxatone… Read More

Steroid Induced Leukocytosis

Mechanism of Steroid Induced Leukocytosis There are 3 major mechanisms responsible for corticosteroid induced granulocytosis: 1. Demargination of neutrophils from endothelial cells (60% of the rise): Recall the leukocyte adhesion cascade in the chapter of inflammation. L-selectins are present in leukocytes that mediates their rolling… Read More

MDR and XDR TB

Antitubercular drug symbols H = Isoniazid R = Rifampicin Z = Pyrazinamide E = Ethambutol S = Streptomycin Km = Kanamycin Cm = Capreomycin Lfx = Levofloxacin Ofx = Ofloxacin Mfx = Moxifloxacin Eto = Ethionamide PAS = Para-aminosalicylic acid Cs = Cycloserine Amx/Clv =… Read More