Gram positive and Gram negative Amoxicillin-clavulanate Tazobactam-piperacillin Carbapenem: Ertapenen, Imipenem, Meropenem Cefuroxime Cefotaxime Ceftriaxone Anaerobes Amoxicillin-clavulanate Tazobactam-piperacillin Carbapenems Clindamycin Metronidazole Pseudomonas Tazobactam-piperacillin Carbapenems (except Ertapenem)…
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Pharmacokinetics Mnemonics
The most important pharmacokinetic parameters from a dosing point of view are: The clearance (CL) – determines the maintenance dose-rate The volume of distribution (Vd)…
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Junction Location Composition Function Remarks Tight junction (Zonula occludens) Epithelial cell-Epithelial cell Claudin and Occludin (attaches to cytoskeleton – actin filament) Prevents paracellular movement of…
Explore more Cell-Cell or Interceullular JunctionsCompetitive, Non-competitive and Uncompetitive Inhibitors
Vmax is the maximum velocity, or how fast the enzyme can go at full ‘‘speed.’’ Vmax is reached when all of the enzyme is in…
Explore more Competitive, Non-competitive and Uncompetitive InhibitorsBeta-oxidation of Fatty Acids : Simplified
Fatty Acid Activation (Cytoplasm) Before undergoing oxidation, fatty acid must be activated first by conversion into Acyl-CoA by the action of Fatty Acyl-CoA synthase (thiokinase).…
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Enzymes: Fatty acid synthase (6 enzymes and 1 Acyl carrier protein molecule) Acetyl-CoA carboxylase (rate-limiting enzyme) Starting material: For palmitate synthesis: Acetyl-CoA For odd number…
Explore more Fatty Acid Synthesis : SimplifiedStructure of Fatty acids and Derivatives : Simplified
Structure Saturated fatty acid: Single bond (“S” for saturated and single bond) Unsaturated fatty acid: Double bond(s), i.e. “D” for Double bonds, Decreased melting temperature…
Explore more Structure of Fatty acids and Derivatives : SimplifiedEliciting Smoking and Alcohol History
Smoking History Ask: Have you ever smoked? If yes – Further ask: For how long? What form? (cigarettes, cigars, pipe, chewed) How much? Quantify smoking…
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