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General concepts

USMLE, PGMEE, MBBS, MD/MS

Antibiotic Spectrums : Cheat sheet

Epomedicine May 20, 2020 No Comments General conceptsPharmacology

Gram positive and Gram negative Amoxicillin-clavulanate Tazobactam-piperacillin Carbapenem: Ertapenen, Imipenem, Meropenem Cefuroxime Cefotaxime Ceftriaxone Anaerobes Amoxicillin-clavulanate Tazobactam-piperacillin Carbapenems Clindamycin Metronidazole Pseudomonas Tazobactam-piperacillin Carbapenems (except Ertapenem)…

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USMLE, PGMEE, MBBS, MD/MS

Pharmacokinetics Mnemonics

Epomedicine Aug 12, 2019 No Comments General conceptsPharmacology

The most important pharmacokinetic parameters from a dosing point of view are: The clearance (CL) – determines the maintenance dose-rate The volume of distribution (Vd)…

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intercellular junctions
USMLE, PGMEE, MBBS, MD/MS

Cell-Cell or Interceullular Junctions

Epomedicine May 22, 2019 No Comments DermatologyGeneral conceptsPhysiology

Junction Location Composition Function Remarks Tight junction (Zonula occludens) Epithelial cell-Epithelial cell Claudin and Occludin (attaches to cytoskeleton – actin filament) Prevents paracellular movement of…

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inhibition_Lineweaver_Burk
USMLE, PGMEE, MBBS, MD/MS

Competitive, Non-competitive and Uncompetitive Inhibitors

Epomedicine Aug 10, 2018 No Comments BiochemistryGeneral conceptsPharmacology

Vmax is the maximum velocity, or how fast the enzyme can go at full ‘‘speed.’’ Vmax is reached when all of the enzyme is in…

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fatty-acid-oxidation
USMLE, PGMEE, MBBS, MD/MS

Beta-oxidation of Fatty Acids : Simplified

Epomedicine Jul 31, 2018 No Comments BiochemistryGeneral concepts

Fatty Acid Activation (Cytoplasm) Before undergoing oxidation, fatty acid must be activated first by conversion into Acyl-CoA by the action of Fatty Acyl-CoA synthase (thiokinase).…

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acetylcoa carboxylase
USMLE, PGMEE, MBBS, MD/MS

Fatty Acid Synthesis : Simplified

Epomedicine Jul 30, 2018 No Comments BiochemistryGeneral concepts

Enzymes: Fatty acid synthase (6 enzymes and 1 Acyl carrier protein molecule) Acetyl-CoA carboxylase (rate-limiting enzyme) Starting material: For palmitate synthesis: Acetyl-CoA For odd number…

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fatty acid
USMLE, PGMEE, MBBS, MD/MS

Structure of Fatty acids and Derivatives : Simplified

Epomedicine Jul 29, 2018 No Comments BiochemistryGeneral concepts

Structure Saturated fatty acid: Single bond (“S” for saturated and single bond) Unsaturated fatty acid: Double bond(s), i.e. “D” for Double bonds, Decreased melting temperature…

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smoking and alcohol assessment
Clinical Skills and Approaches

Eliciting Smoking and Alcohol History

Epomedicine Nov 10, 2017 1 Comment Clinical examinationGeneral concepts

Smoking History Ask: Have you ever smoked? If yes – Further ask: For how long? What form? (cigarettes, cigars, pipe, chewed) How much? Quantify smoking…

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RSS PGMEE, USMLE, MBBS

  • Tendon Transfer Principles : Mnemonic
  • Tourniquet Paralysis Syndrome
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