Types Type Pathology 25(OH) D 1,25(OH)2 D PTH Ca PO4 ALP Additional clinical findings Treatment Vitamin D deficiency (Nutritional) Hypovitaminosis D 🡢 Hypocalcemia 🡢 Secondary hyperparathyroidism 🡢 Rise of serum calcium towards normal level ↓ ↓ ↑ ↓/= ↓ ↑ Rachitic rosaryBowing of kneesMuscle hypotoniaWaddling gaitDental diseaseLooser zones/Milkman’s fracture (pseudofracture…
Category: PGMEE, MRCS, USMLE, MBBS, MD/MS
Medical knowledge in bullet points with understandable language, simplified images and graspable mnemonics.
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Calcium Metabolism
Functions Mnemonic: Six ‘C’s Contraction of muscles (Coupling of excitation-contraction) Conduction in nerves Cardiac function Coagulation in blood (Co-factor) Communication (intracellular messengers) for hormones, autacoids and transmitters Cementing (mineralization) of bone – Compressive strength Distribution Average young adult = 1200 gm calcium 99% in bone as calcium hydroxyapatite 1% in…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Hawkin’s Classification for Talus Fractures : Mnemonic
Mnemonic: NISA 10-50-90-100 Type I – Non-displaced Neck fracture (upto 10% risk of AVN) 1 blood vessel damaged (entering talar neck) Management: 8 weeks in cast and 4 weeks in CAM cast Type II – Type I + Inferior (subtalar) subluxation/dislocation (upto 50% risk of AVN) 2 blood vessels damaged…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Swan neck deformity vs Boutonniere deformity
Alterations in the relationships between the balanced extrinsic and intrinsic musculature of the hand due to trauma or secondary to the effects of systemic disease may cause the development of functional deformities such as a boutonnière or swan-neck deformity. Swan-neck deformity Boutonniere deformity Deformity PIPJ Hyperextension PIPJ Flexion DIPJ Flexion…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Management of Anti-tubercular therapy (ATT) induced Hepatitis
Definition of ATT induced hepatitis ALT > 3 X Normal + Symptoms OR ALT > 5 X Normal without Symptoms Management of ATT induced hepatitis 1. Hold all TB drugs for 7-10 days. Wait before restarting ATT until: Symptoms: Resolve ALT <2.5 X Normal For severe TB, patients should be…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Osteoid Osteoma : Mnemonic
Epidemiology and Clinical features Mnemonic: LMNOP Lower extremity predilection (proximal femur > tibial diaphysis) Male predilection (2:1 to 3:1) Night pain relieved by NSAIDs (absent in osteoblastoma) Osteogenic benign tumor Prostaglandins (PGE2) and Cyclooxygenase (COX1 and 2) release by nidus (explains night pain and response to NSAIDs) 3 Concentric layers…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Pregabalin vs Gabapentin
Both pregabalin and gabapentin are GABA analogues that bind to presynaptic neuron’s voltage-gated calcium channels (VGCC), specifically to the alpha-2-delta protein leading to reduced calcium influx at the nerve terminals. This leads to reduced release of excitatory neurotransmitters. Though the compounds are similar they have few important differences that must…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Pirani Score and Dimeglio Classification for Clubfoot Assessment
Pirani socre Pirani score for assessment of clubfoot (CTEV) consists of 6 parameters (3 each in midfoot and hindfoot) which is scored as 0, 0.5 or 1 with a maximum possible score of 6. The parameters can be remembered using the mnemonic: PER TOM Posterior crease Empty heel Rigid equinus…