Gram positive and Gram negative Amoxicillin-clavulanate Tazobactam-piperacillin Carbapenem: Ertapenen, Imipenem, Meropenem Cefuroxime Cefotaxime Ceftriaxone Anaerobes Amoxicillin-clavulanate Tazobactam-piperacillin Carbapenems Clindamycin Metronidazole Pseudomonas Tazobactam-piperacillin Carbapenems (except Ertapenem) Ceftazidime, Cefoperazone, Cefepime Gentamicin, Amikacin, Tobramycin Ciprofloxacin Colistin Aztreonam Only gram positive Vancomycin Teicoplanin Linezolid Daptomycin Only gram negative Ceftazidime Colistin Aztreonam “Non-culturable” bacteria Macrolides:…
Tag: Pharmacology
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Calcium Channel Blockers : Mnemonic
Dihydropyridines Mnemonics:a. D for “-dipine”b. D for Dilation of vessels Nifedipine Nicardipine Isradipine Felodipine Amlodipine Non-dihydropyridines Mnemonics:a. N-D for Non “-dipines”b. N-D for Node supression + Dilation of vessels Verapamil Diltiazem
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Simplified Guide to Statin Therapy
Statins Equivalent Dose Mnemonic: PRASLPF 2-5-10-20-40-40-80 Pituvastatin 2 mg Rosuvastatin 5 mg Atorvastatin 10 mg Simvastatin 20 mg Lovastatin 40 mg Pravastatin 40 mg Fluvastatin 80 mg Intensity of Statins a. High intensity (LDL lowering >/= 50%) Atorvastatin 40-80 mg Rosuvastatin 20-40 mg b. Moderate intenstity (LDL lowering 30-49%) Atorvastatin…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Beta-Blockers : Mnemonics
We have 1 heart and 2 lungs. a. B1 – heartb. B2 – bronchial wall Cardioselective (B1) vs Non-selective (B1 and B2) beta blockers Beta blockers with 1st letter from A to N are Cardioselective: Acebutolol Atenolol Bispoprolol Betaxolol Celiprolol Esmolol Metoprolol Nebivolol Nebivolol = NO donor Beta blockers with…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Pharmacokinetics Mnemonics
ADME is the 4-letter acronym used to describe pharmacokinetics: ABCD is another 4-letter acronym used to describe pharmacokinetics: The most important pharmacokinetic parameters from a dosing point of view are: Vd = Volume of distributionD = DoseCo = Concentration in plasmaCL = ClearancekE = Elimination constantt1/2 = Half life In…
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Acyclovir Post-exposure Prophylaxis for Varicella: Is it helpful?
Dose: 80 mg/kg/day in 4 divided doses for 7 days; maximum 800 mg 4 times a day Time to start prophylaxis: 7-10 days after exposure (late incubation period) Indication: People without evidence of immunity and with contraindications for varicella vaccination (VZIg) Results from some studies Among 27 children in the…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Competitive, Non-competitive and Uncompetitive Inhibitors
Vmax is the maximum velocity, or how fast the enzyme can go at full ‘‘speed.’’ Vmax is reached when all of the enzyme is in the enzyme–substrate complex. Km is the substrate concentration at which v = 1/2 Vmax. Km approximately describes the affinity of the substrate for the enzyme….
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Signaling Pathways of Hormones : Mnemonic
cAMP Mechanism Mnemonic: FLAT CAMP B-HCGS Remember “B-FLAT” mnemonic for hormones secreted by basophilic cells of the anterior pituitary. This is the same “FLAT” here. Also CAMP matches cAMP. Beta-HCG works by cAMP mechanism. All 2 except Beta 1 and 5-HT1 So, this is an easy mnemonic to remember. FSH…