Signaling Pathways of Hormones : Mnemonic

second messengers

cAMP Mechanism

Mnemonic: FLAT CAMP B-HCGS

Remember β€œB-FLAT” mnemonic for hormones secreted by basophilic cells of the anterior pituitary. This is the same β€œFLAT” here.

Also CAMP matches cAMP.

Beta-HCG works by cAMP mechanism.

All 2 except Beta 1 and 5-HT1

So, this is an easy mnemonic to remember.

  1. FSH
  2. LH (+ Lipotropin)
  3. ACTH
  4. TSH
  5. CRH
  6. Aquaporin ADH (V2), Alpha 2 adrenergic (Both have 2) and Adenosine A2
  7. MSH and M2/M4
  8. PTH, Prolactin Inhibiting Factor (Dopamine), PGE2-EP2 and PGI2
  9. Beta adrenergics (Both 1 and 2 – Beta 1 and Beta 2)
  10. HCG and Histamine H2 (This is also 2)
  11. Calcitonin
  12. Glucagon and GABA-B (Assume B = 2)
  13. Somatostatin, Secretin and Serotonin (5HT-1 and 5-HT4)

receptor mechanism

c-GMP Mechanism

Mnemonic: Starts with β€œN”

  1. Natriuretic peptides (ANP and BNP)
  2. Nitric oxide (NO)
  3. Night vision (photic response of retinal rods)

IP3/DAG Mechanism

Mnemonic:

  1. Hypothalamic hormones except CRH and V2 ADH
  2. All 1 except Beta 1, Dopamine 1 and 5-HT1 (c-AMP mechanism)
  3. BCGS
  4. 3 PΒ (Matches with IP3)
  1. GnRH
  2. TRH
  3. GHRH
  4. Oxytocin (produced by hypothalamus and stored in posterior pituitary)
  5. V1 (ADH)
  6. Alpha 1 adrenergic
  7. H1
  8. AT1 (Angiotensin II)
  9. Endothelin-1
  10. M1/M3/M5
  11. Bradykinin (B1 and B2)
  12. Cholecystokinin
  13. Gastrin and Ghrelin
  14. Serotonin (5-HT2)
  15. substance P
  16. PDGF
  17. Prostaglandins and leukotrienes (PGE2 – EP1/EP3, PGF, Thromboxane, LTB4, cysLT )

Tyrosine kinase (MAP and JAK/STAT) Mechanism

Mnemonic:

  1. All that have β€œGrowthβ€œ.
  2. PIGLET (Remember the mnemonic PiG for anterior pitutiary hormones secreted by acidophilic cells. Both prolactin and growth hormone use tyrosine kinase receptor mechanism)
  3. MAP kinase pathway – Think growth factors (insulin, IGF-1, FGF, PDGF, EGF)
  4. Non-receptor (JAK/STAT) pathway – Others
  1. Growth factors (EGF, FGF, PDGF, NGF, IGF-1 and 2) and Growth hormone
  2. PIGLET:
    • Prolactin
    • Insulin
    • G-CSF
    • Lymphokines (IL-2, IL-6, IFN, TNF, growth factors, GM-CSF) and Leptin
    • Erythropoietin
    • Thrombopoietin

Hormone response elements (HRE) on DNA

Mnemonic: All lipohilic hormones – Steroids and Thyroids

  1. Thyroid hormone
  2. Cortisol
  3. Aldosterone
  4. Testosterone
  5. Estrogen
  6. Progesterone
  7. Vitamin D

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