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Biochemistry

dna replication
USMLE, PGMEE, MBBS, MD/MS

DNA Replication Explained With Zipper Model

Dr. Sulabh Kumar Shrestha, PGY2 Orthopedics Jan 25, 2017 No Comments BiochemistryGeneral concepts

Imagine DNA as a zipper Prokaryotic DNA as a zipper with single slider (single origin of replication) and Eukaryotic DNA as a zipper with two…

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purines and pyrimidine bases
USMLE, PGMEE, MBBS, MD/MS

Purine and Pyrimidines : Structure, Synthesis and Metabolism

Epomedicine Jan 25, 2017 1 Comment BiochemistryGeneral concepts

Purines and Pyrimidines Bases Purines = 2 rings Adenine Guanine Hypoxanthine (Deaminated Adenine) Adenine to Hypoxanthine deamination is mediated by Adenosine deaminase which is decreased…

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trinucleotide repeat disorders
USMLE, PGMEE, MBBS, MD/MS

Trinucleotide Repeat Disorders and Anticipation Mnemonics

Epomedicine Jan 23, 2017 No Comments BiochemistryGeneral conceptsPathology

Anticipation in genetics refers to an increase in severity and decrease in age of onset in successive generations, most likely due to increased size of…

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pedigree analysis
USMLE, PGMEE, MBBS, MD/MS

Solving Pedigree Analysis in 3 steps

Epomedicine Jan 23, 2017 2 Comments BiochemistryGeneral conceptsPathology

First: Look for Mitochondrial Inheritance Female transmits disease to all the offsprings (both males and females). Male doesn’t transmit the disease and only the females…

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lysosomal storage disorders
USMLE, PGMEE, MBBS, MD/MS

Lysosomal Storage Disorders Made Easy

Dr. Sulabh Kumar Shrestha, PGY2 Orthopedics Jan 22, 2017 2 Comments BiochemistryNervous systemPediatrics

Among the common lysosomal storage disorders: Two of them are Mucopolysaccharidoses (Hunter and Hurler syndrome) Pompe’s disease is Glycogen Storage Disease. Others are Sphingolipidoses. Inheritance…

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glucose-6-phosphate
USMLE, PGMEE, MBBS, MD/MS

Glucose 6 Phosphate : Central to Glucose Metabolism

Epomedicine Jan 22, 2017 No Comments BiochemistryGeneral concepts

Glucose-6-Phosphate central to the 4 major metabolic pathways of glucose, i.e. glycolysis, gluconeogenesis, glycogenesis, glycogenolysis and HMP shunt (Pentose phosphate pathway). Glucose is immediately phosphorylated…

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glycogen stroage diseases
USMLE, PGMEE, MBBS, MD/MS

Glycogen Storage Diseases with Mnemonics

Dr. Sulabh Kumar Shrestha, PGY2 Orthopedics Jan 22, 2017 2 Comments BiochemistryPediatrics

Once again, I’m back with a biochemistry topic that everyone hates. Let’s try to break the topic, simplify it and cover all the important aspects…

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normal serum electrophoresis
USMLE, PGMEE, MBBS, MD/MS

M-spike

Epomedicine Oct 24, 2016 1 Comment BiochemistryHematologyInternal medicine

Synonyms: Monoclonal spike, M-protein spike, Monoclonal band, Monoclonal gammopathy Tests showing M-spike Serum Protein Electrophoresis (SPEP) Urine Protein Electrophoresis (UPEP) Normal SPEP or UPEP Electrophoresis is…

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