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Biochemistry

dna replication
USMLE, PGMEE, MBBS, MD/MS

DNA Replication Explained With Zipper Model

Dr. Sulabh Kumar Shrestha , PGY3 Orthopedics Jan 25, 2017 1 Comment BiochemistryGeneral concepts

Imagine DNA as a zipper Prokaryotic DNA as a zipper with single slider (single origin of replication) and Eukaryotic DNA as a zipper with two…

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purines and pyrimidine bases
USMLE, PGMEE, MBBS, MD/MS

Purine and Pyrimidines : Structure, Synthesis and Metabolism

Epomedicine Jan 25, 2017 1 Comment BiochemistryGeneral concepts

Purines and Pyrimidines Bases Purines = 2 rings Adenine Guanine Hypoxanthine (Deaminated Adenine) Adenine to Hypoxanthine deamination is mediated by Adenosine deaminase which is decreased…

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trinucleotide repeat disorders
USMLE, PGMEE, MBBS, MD/MS

Trinucleotide Repeat Disorders and Anticipation Mnemonics

Epomedicine Jan 23, 2017 1 Comment BiochemistryGeneral conceptsPathology

Anticipation in genetics refers to an increase in severity and decrease in age of onset in successive generations, most likely due to increased size of…

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pedigree analysis
USMLE, PGMEE, MBBS, MD/MS

Solving Pedigree Analysis in 3 steps

Epomedicine Jan 23, 2017 4 Comments BiochemistryGeneral conceptsPathology

First: Look for Mitochondrial Inheritance Female transmits disease to all the offsprings (both males and females). Male doesn’t transmit the disease and only the females…

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lysosomal storage disorders
USMLE, PGMEE, MBBS, MD/MS

Lysosomal Storage Disorders Made Easy

Dr. Sulabh Kumar Shrestha , PGY3 Orthopedics Jan 22, 2017 2 Comments BiochemistryNervous systemPediatrics

Among the common lysosomal storage disorders: Two of them are Mucopolysaccharidoses (Hunter and Hurler syndrome) Pompe’s disease is Glycogen Storage Disease. Others are Sphingolipidoses. Inheritance…

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glucose-6-phosphate
USMLE, PGMEE, MBBS, MD/MS

Glucose 6 Phosphate : Central to Glucose Metabolism

Epomedicine Jan 22, 2017 No Comments BiochemistryGeneral concepts

Glucose-6-Phosphate central to the 4 major metabolic pathways of glucose, i.e. glycolysis, gluconeogenesis, glycogenesis, glycogenolysis and HMP shunt (Pentose phosphate pathway). Glucose is immediately phosphorylated…

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glycogen stroage diseases
USMLE, PGMEE, MBBS, MD/MS

Glycogen Storage Diseases with Mnemonics

Dr. Sulabh Kumar Shrestha , PGY3 Orthopedics Jan 22, 2017 3 Comments BiochemistryPediatrics

Once again, I’m back with a biochemistry topic that everyone hates. Let’s try to break the topic, simplify it and cover all the important aspects…

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normal serum electrophoresis
USMLE, PGMEE, MBBS, MD/MS

M-spike

Epomedicine Oct 24, 2016 1 Comment BiochemistryHematologyInternal medicine

Synonyms: Monoclonal spike, M-protein spike, Monoclonal band, Monoclonal gammopathy Tests showing M-spike Serum Protein Electrophoresis (SPEP) Urine Protein Electrophoresis (UPEP) Normal SPEP or UPEP Electrophoresis is…

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