PGMEE, MRCS, USMLE, MBBS, MD/MS

Jod-Basedow Phenomenon vs Wolff-Chaikoff Effect : Mnemonic

Epomedicine May 22, 2024 No Comments

Last modified: May 22, 2024

Jod = Addition in Hindi or Nepali = Iodine induced Hyperthyroidisim

ChaikOFF = Thyroid hormone synthesis is switched OFF = Iodine induced Hypothyroidisim

wolff-chaikoff and jod-basedow phenomenon
Wolff–Chaikoff effect And Jod-Basedow effect. (openmed.co.in) [CC BY-NC-SA 4.0]

Mechanism

Thyroid Hormone Function & Synthesis : Mnemonics
Jod-BasedowWolff-Chaikoff
Pre-requisiteAbnormal thyroid gland free from pituitary controlThyroid gland under pituitary control
ConditionsEndemic goitre, Grave’s disease, Toxic multinodular goitre, Thyroid adenomaNormal thyroid (Euthyroid), Hyperthyroid (Grave’s disease)
MechanismExcess iodine stimulates thyroid iodide organificationExcess iodine inhibits thyroid iodide organification
ResultIodine induced hyperthyroidismIodine induced hypothyroidism
a. Normal thyroid (Euthyroid): Escapes after 10 days
b. Autoimmune thyroid: Persists After

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