Jod-Basedow Phenomenon vs Wolff-Chaikoff Effect : Mnemonic

Epomedicine, May 22, 2024May 22, 2024

Jod = Addition in Hindi or Nepali = Iodine induced Hyperthyroidisim

ChaikOFF = Thyroid hormone synthesis is switched OFF = Iodine induced Hypothyroidisim

wolff-chaikoff and jod-basedow phenomenon — Wolff–Chaikoff effect And Jod-Basedow effect. (openmed.co.in) [CC BY-NC-SA 4.0]

Mechanism

Thyroid Hormone Function & Synthesis : Mnemonics

	Jod-Basedow	Wolff-Chaikoff
Pre-requisite	Abnormal thyroid gland free from pituitary control	Thyroid gland under pituitary control
Conditions	Endemic goitre, Grave’s disease, Toxic multinodular goitre, Thyroid adenoma	Normal thyroid (Euthyroid), Hyperthyroid (Grave’s disease)
Mechanism	Excess iodine stimulates thyroid iodide organification	Excess iodine inhibits thyroid iodide organification
Result	Iodine induced hyperthyroidism	Iodine induced hypothyroidism a. Normal thyroid (Euthyroid): Escapes after 10 days b. Autoimmune thyroid: Persists After

PGMEE, MRCS, USMLE, MBBS, MD/MS

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Mechanism

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