Jod-Basedow Phenomenon vs Wolff-Chaikoff Effect : Mnemonic


Pre-requisiteAbnormal thyroid gland free from pituitary controlThyroid gland under pituitary control
ConditionsEndemic goitre, Grave’s disease, Toxic multinodular goitre, Thyroid adenomaNormal thyroid (Euthyroid), Hyperthyroid (Grave’s disease)
MechanismExcess iodine stimulates thyroid iodide organificationExcess iodine inhibits thyroid iodide organification
ResultIodine induced hyperthyroidismIodine induced hypothyroidism
a. Normal thyroid (Euthyroid): Escapes after 10 days
b. Autoimmune thyroid: Persists After

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