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Leukocyte Adhesion Cascade and Defect

Capture or Tethering Increased vascular permeability and vasodilation are mediated by inflammatory mediators like histamine released by inflammatory cells in response to PAMPs expressed by pathogens. Hemoconcentration (owing to increased vascular permeability) and decreased velocity of blood flow (owing to vasodilation) leads to peripheral pooling… Read More

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