Ollier’s disease
Maffucci syndrome
Diagnosis (Berlin Criteria) Mnemonic A R D S Acute Lung Injury (ALI) Acute onset (<7 days) Ratio PaO2/FiO2 ≤300 mmHg or 40 kPa Diffuse bilateral pulmonary infiltrates on CXR Swan-Ganz pulmonary wedge pressure ≤18 mmHg or No evidence of Left atrial hypertension Acute Respiratory Distress Syndrome (ARDS) Acute onset (<7…
Structure of erythropoietin (EPO) Glycoprotein hormone 165 amino acids Molecular mass – 30 kDa Site of production/synthesis of erythropoietin (EPO) Kidneys (75-90%): Peritubular interstitial cells Liver (15%; chief source in fetus and neonates): Centrilobular hepatocytes After birth, erythropoietin is not detectable until 8-12 weeks after birth leading to physiological anaemia…
Structure of Heme Heme is a ferro-proto-porphyrin. Heme = Protoporphyrin IX ring + Iron (Fe) in center Protoporphyrin IX = porphyrin with attachment to 4 Methyl, 2 Propionyl and 2 Vinyl groups. Porphyrin = Cyclic structure with 4 pyrrole rings Pyrrole rings are derived from Porphobilinogen (PBG) Hydroxymethylbilane = Linear…