![hematopoiesis schematic](https://epomedicine.com/wp-content/uploads/2019/05/Hematopoiesis_simple.png)
a. SCF (Steel factor): Multipontent stem cells
b. IL-3: Myeloid stem cells (“3” turned down looks like “m“)
c. IL-7: Lymphoid stem cell (“L” turned up looks like “7“)
d. GM-CSF (Granulocyte macrophage Colony stimulating factor): Myeloid lineage (Erythrocytes, Thrombocytes, Granulocytes and Monocytes)
Pharmaceutical: Sargramostim
e. G-CSF: Granulocytes (Neutrophil, Eosinophil, Basophil)
Pharmaceutical: Filgrastim, peg-filgrastim
f. M-CSF: Monocytes
g. EPO (Erythropoietin): Erythrocytes
Pharmaceutical: Epoietin-alpha, Darbepoietin
h. TPO (Thrombopoietin): Thrombocytes
i. IL-11: Thrombocytes (11 letters in THROMBOCYTE)
Pharmaceutical: Oprelvekin
j. IL-5: Eosinophil (E is the 5th letter)
k. IL-2: T-cells (“T” for “Two” and “T-lymphocytes”)
l. IL-4: B-cells (B4 – Basophill secrete IL-4 → B cell growth)
m. IL-6: Plasma cells (6 letters in PLASMA)
n. IL-15: NK cells (15 letters in GRANULAR KILLERS)
Some other roles of cytokins:
1. IL-8: Neutrophil chemotactic factor
2. IL-12: TH1 differentiation and NK cell activation
3. IFN-gamma: Inhibits TH2 differentiation
4. IL-4: TH2 differentiation and class switching to IgE and IgG
5. IL-5: Class switching to IgA
6. IL-10: Cytokine synthesis inhibition in NK and TH1 cells
7. IL-1: Lymphocyte activating factor
![dr. sulabh kumar shrestha](https://epomedicine.com/wp-content/uploads/2020/07/profile.jpg)
He is the section editor of Orthopedics in Epomedicine. He searches for and share simpler ways to make complicated medical topics simple. He also loves writing poetry, listening and playing music.