Diacerin is a DMOAD (Diseases Modifying Osteoarthritis Drug) –
D – Diarrhea (not recommended in >65 years – more vulnerable to diarrhea)
I – IL-1 Inhibition
A – Anthraquinone
C – Chondroprotective effects
E – Eczema
R – Rashes
I – Increase in hepatic enzymes (contraindicated in patients with history of liver diseases)
N – NSAID like efficacy after 1st month of treatment
Many students feel that, this is one of the most difficult to explain topic in Immunology. Here, we will try to explain the process and clinical relevance of V(D)J or Somatic recombination in simple and interactive way. Question your mind Humans only have about 25,000 genes. Since, an antibody made…
Mechanism of Steroid Induced Leukocytosis There are 3 major mechanisms responsible for corticosteroid induced granulocytosis: 1. Demargination of neutrophils from endothelial cells (60% of the rise): Recall the leukocyte adhesion cascade in the chapter of inflammation. L-selectins are present in leukocytes that mediates their rolling on the endothelial lining of…
Stage GFR criteria Urine output criteria Mnemonic 1, 2, 3, 4 1, 2, 3 1. Risk Cr ↑ 1.5-2 XGFR ↓ 25-50% (>1/4) <0.5 ml/kg/hr X 6-12 (>1/4 day) 2. Injury Cr ↑ 2-3 XGFR ↓ >50-75% (>2/4) <0.5 ml/kg/hr X >12-24 hrs (>2/4 day) 3. Failure Cr ↑ >3…