Diacerin is a DMOAD (Diseases Modifying Osteoarthritis Drug) –
D – Diarrhea (not recommended in >65 years – more vulnerable to diarrhea)
I – IL-1 Inhibition
A – Anthraquinone
C – Chondroprotective effects
E – Eczema
R – Rashes
I – Increase in hepatic enzymes (contraindicated in patients with history of liver diseases)
N – NSAID like efficacy after 1st month of treatment
You must have seen the statement in First Aid that says – low serum magnesium causes increase in Parathyroid hormone secretion and very low serum magnesium causes decrease in Parathyroid hormone secretion. Doesn’t this make you curious? Let’s explore the underlying mechanism in depth. How Calcium and Magnesium Mediated PTH…
Etiology Mnemonic: RSTUV Lichtman Classification and Management Stage Description Treatment Mnemonic: ABCD Mnemonic: ABCD I Abnormal MRI (decreased T1 intensity; variable T2 intensity) or scintigraphy Analgesics + immobilization II Bone sclerosis ± Bone breaks (fracture lines) Bony procedures:1. Negative or Neutral ulnar variance: Joint levelling procedure (Radius shortening osteotomy; Ulnar…
Normal distribution Non-normal distribution a. Positive skew: Longer or fatter tail on right b. Negative skew: Longer or fatter tail on left 2X2 tables Disease present Disease absent Test positive TP FP Test negative FN TN Event Non-event Exposed or Treatment a b Non-exposed or Placebo c d Formulae Incidence…