Diacerin is a DMOAD (Diseases Modifying Osteoarthritis Drug) –
D – Diarrhea (not recommended in >65 years – more vulnerable to diarrhea)
I – IL-1 Inhibition
A – Anthraquinone
C – Chondroprotective effects
E – Eczema
R – Rashes
I – Increase in hepatic enzymes (contraindicated in patients with history of liver diseases)
N – NSAID like efficacy after 1st month of treatment
Mnemonic: Remember “S” for Scheurmann Structural kyphosis (sagittal deformity) of thoracic or thoracolumbar spine Skeletally immature sons (0.4-10% of adolescents between 10-14 years; onset with prepubertal growth spurt; M:F = 2-7:1) Strong hereditary (genetic) predisposition and Several theories: Scheurmann’s vertebral epiphyseal disturbance theory Schmorl’s nodes (herniation of disc material into…
Limbic system is complex both structurally and functionally. It is located on either side of the thalamus, immediately below the cerebrum and consists of both the grey mater and white mater. Let us simplify the structure of limbic system: Hypothalamus is central to the limbic system Limbic cortex: 2 “C”…
Haldane effect Mnemonic: HALD Bohr Effect Mnemonic: BOHR