Diacerin is a DMOAD (Diseases Modifying Osteoarthritis Drug) –
D – Diarrhea (not recommended in >65 years – more vulnerable to diarrhea)
I – IL-1 Inhibition
A – Anthraquinone
C – Chondroprotective effects
E – Eczema
R – Rashes
I – Increase in hepatic enzymes (contraindicated in patients with history of liver diseases)
N – NSAID like efficacy after 1st month of treatment
Bilirubin-induced neurologic dysfunction (BIND) Score is used to assess bilirubin induced encephalopathy in neonates with severe hyperbilirubinemia. Johnson et al developed the BIND score to help identify an infant who requires more aggressive monitoring and management. The scoring system has 3 parameters: 1. Cry pattern 2. Behavior and mental status…
Both pregabalin and gabapentin are GABA analogues that bind to presynaptic neuron’s voltage-gated calcium channels (VGCC), specifically to the alpha-2-delta protein leading to reduced calcium influx at the nerve terminals. This leads to reduced release of excitatory neurotransmitters. Though the compounds are similar they have few important differences that must…
Pes Anserinus is composed of the combination of tendinous insertions of the sartorius, gracilis and semitendinosus muscles (guy ropes muscles) which attaches to the medial side of tibia to generate a “goose’s foot” like appearance. These three muscles are mainly flexors of the knee but also have a role in…