Classification Non-nitrogen containing (1st generation): Etidronate Clodronate Tiludronate Nitrogen containing (2nd and 3rd generation): a. 2nd generation (alky-amino nitrogen containing): Pamidronate Alendronate Ibadronate Olpadronate b. 3rd generation (heterocyclic nitrogen containing): Risedronate Zoledronate Chemical structure Stable derivatives of inorganic pyrophosphate (PPi) Mechanism of action Strong attachment to hydroxyapatite mineral found in…
Tag: Pharmacology
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Antimicrobial Mechanism of Actions – Everything you need to know
Cell Wall Synthesis Inhibitors A peptidoglycan monomer consists of 2 joined amino-sugars, N-acetyl glucosamine (NAG) and N-acetyle muramic acid (NAM), with a pentapeptide coming off of the NAM. So, a peptidoglycan monomer is a NAG-NAM-pentapeptide. These peptidoglycan monomers are synthesized in cytosol and transported across cytoplasmic membrane by Bactoprenols (BP)….
Clinical Skills and Approaches 
Drug Eruptions – When the Solution becomes Problem
Before we start to develop our understanding of the drug eruptions. Let’s first lay down the foundation by clearing some basic concepts. What is an Allergy? What is meant by an adverse drug reaction? What is the diversity of allergic reactions due to drugs? Allergy This is a hypersensitivity disorder…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Antibiotic Spectrums : Cheat sheet
Gram positive and Gram negative Amoxicillin-clavulanate Tazobactam-piperacillin Carbapenem: Ertapenen, Imipenem, Meropenem Cefuroxime Cefotaxime Ceftriaxone Anaerobes Amoxicillin-clavulanate Tazobactam-piperacillin Carbapenems Clindamycin Metronidazole Pseudomonas Tazobactam-piperacillin Carbapenems (except Ertapenem) Ceftazidime, Cefoperazone, Cefepime Gentamicin, Amikacin, Tobramycin Ciprofloxacin Colistin Aztreonam Only gram positive Vancomycin Teicoplanin Linezolid Daptomycin Only gram negative Ceftazidime Colistin Aztreonam “Non-culturable” bacteria Macrolides:…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Calcium Channel Blockers : Mnemonic
Dihydropyridines Mnemonics:a. D for “-dipine”b. D for Dilation of vessels Nifedipine Nicardipine Isradipine Felodipine Amlodipine Non-dihydropyridines Mnemonics:a. N-D for Non “-dipines”b. N-D for Node supression + Dilation of vessels Verapamil Diltiazem
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Simplified Guide to Statin Therapy
Statins Equivalent Dose Mnemonic: PRASLPF 2-5-10-20-40-40-80 Pituvastatin 2 mg Rosuvastatin 5 mg Atorvastatin 10 mg Simvastatin 20 mg Lovastatin 40 mg Pravastatin 40 mg Fluvastatin 80 mg Intensity of Statins a. High intensity (LDL lowering >/= 50%) Atorvastatin 40-80 mg Rosuvastatin 20-40 mg b. Moderate intenstity (LDL lowering 30-49%) Atorvastatin…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Beta-Blockers : Mnemonics
We have 1 heart and 2 lungs. a. B1 – heartb. B2 – bronchial wall Cardioselective (B1) vs Non-selective (B1 and B2) beta blockers Beta blockers with 1st letter from A to N are Cardioselective: Acebutolol Atenolol Bispoprolol Betaxolol Celiprolol Esmolol Metoprolol Nebivolol Nebivolol = NO donor Beta blockers with…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Pharmacokinetics Mnemonics
ADME is the 4-letter acronym used to describe pharmacokinetics: ABCD is another 4-letter acronym used to describe pharmacokinetics: The most important pharmacokinetic parameters from a dosing point of view are: Vd = Volume of distributionD = DoseCo = Concentration in plasmaCL = ClearancekE = Elimination constantt1/2 = Half life In…