Methotrexate is a dihydrofolate reductase (DHFRase) inhibitor which inhibits DNA repair, synthesis and cellular replication. Actively proliferating tissues such as malignant cells, bone marrow, fetal…
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Pharmacology
Ketamine : Mnemonic
K: Kids (Induction agent of choice in children) E: Emergence reaction (floating sensations, vivid dreams and hallucination; reduced using benzodiazepines), Enantiomers (S-Ketamine and R-Ketamine) T:…
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Pharmacology of Clindamycin : Mnemonic
Class: Lincosamide Mechanism of action: Binds 50S subunit of ribosome and inhibits translation – bacteriostatic (Remember the mnemonic: buy AT 30 & CELLS at 50)…
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NSAIDs : Mnemonics
Classification Mnemonic: Prescribed By SOFIA Propionic acid derivatives: Ibuprofen, Ketoprofen, Flurbiprofen, Naproxen Pyrrolo-pyrrole derivates: Ketoroloac Pyrazolone derivatives: Phenylbutazone, Oxybutazone Benzoxazocine derivatives: Nefopam Salicyaltes: Aspirin Selective…
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Management of Anti-tubercular therapy (ATT) induced Hepatitis
Definition of ATT induced hepatitis ALT > 3 X Normal + Symptoms OR ALT > 5 X Normal without Symptoms Management of ATT induced hepatitis…
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Pregabalin vs Gabapentin
Both pregabalin and gabapentin are GABA analogues that bind to presynaptic neuron’s voltage-gated calcium channels (VGCC), specifically to the alpha-2-delta protein leading to reduced calcium…
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Atropine Induced Paradoxical Bradycardia
Atropine induced paradoxical bradycardia is the sinus bradyarrhythmia following low-dose atropine resulting from the paradoxical slowing in the sinoatrial (SA) node discharge rate. Mechanism of…
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Pregabalin : Pharmacology
Pharmacokinetics After oral ingestion, Pregabalin is rapidly absorbed (Tmax 1.3 hr) Bioavailability is >90% and independent of dose Pregabalin is NOT protein bound Vd is…
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