Adenoma-carcinoma sequence is a stepwise development of normal epithelium to carcinoma due to accumulation of mutations over a number of years leading to activation of oncogenes and loss of tumor suppressor genes. One of the pathways follows adenoma–carcinoma sequence, that is, normal → adenoma → carcinoma. The other is pertaining…
Tag: Oncology
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Lynch Syndrome (HNPCC) : Mnemonics
Inheritance: Autosomal Dominant (AD) Cause: Microsatellite instability (MLH1, MSH2 mismatch repair gene mutation) Types: Amsterdam II Criteria for Diagnosis Mnemonic: 3-2-1-0 rule Colorectal cancers: More likely to be mucinous and right-sided Treatment: Total colectomy with ilio-rectal anastomosis Annual screening: Age 25 onwards or beginning no later than 5 years before…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Carcinoid Tumors : Mnemonic
Origin: Neuroendocrine cells Location: Lungs, Bronchi, Trachea, Gastrointestinal tract Synthesize: Biogenic amines (mainly serotonin which is metabolied to 5-HIAA) 5 Manifestations Mnemonic: 5-HIAAS 1. Heart disease (2/3 patients) 2. Intestinal manifestations 3. Airway obstruction 4. Asthma 5. Skin manifestations Alternative mnemonic: CARCinoid Rule of 1/3 Surgery for appendiceal carcinoid tumor…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Glucagonoma : 6 D’s
Glucagonoma is an alpha-cell tumor of pancreas. Mnemonic: 6 D’s 1. Diabetes 2. Dermatitis (Necrolytic migratory erythema) 3. Declining weight 4. Diarrhea 5. Deep vein thrombosis 6. Dilated cardiomyopathy
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Thyroid Tumors : Mnemonics
Papillary carcinoma Follicular carcinoma Medullary carcinoma Mnemonic: MENACED Anaplastic carcinoma
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Staging and Grading of Bone Tumors (Neoplasm)
Enneking (MSTS) Staging for Malignant Bone Tumors Stage Grade Site Metastasis IA Low Intra-compartmental None IB Low Extra-compartmental None IIA High Intra-compartmental None IIB High Extra-compartmental None III Any Any Regional or Distant Low-grade tumors generally have few mitotic figures, little if any cellular atypia, and have a relatively non-infiltrative…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Osteochondroma : Mnemonics
Features of Osteochondroma Mnemonic: Six “C” Commonest benign bone tumor Continue to grow until Closure of physis Cartilage cap (appears larger clinically than in X-ray) Continuous with native bone (cortex and medullary canal) Cane (pedunculated/stalked points away from joint and sessile/broad based have higher risk of malignant degeneration) Change (mutation)…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Osteoid Osteoma : Mnemonic
Epidemiology and Clinical features Mnemonic: LMNOP Lower extremity predilection (proximal femur > tibial diaphysis) Male predilection (2:1 to 3:1) Night pain relieved by NSAIDs (absent in osteoblastoma) Osteogenic benign tumor Prostaglandins (PGE2) and Cyclooxygenase (COX1 and 2) release by nidus (explains night pain and response to NSAIDs) 3 Concentric layers…