Friedreich’s Ataxia : Mnemonic

Friedreich’s ataxia is a hereditary spinocerebellar degenerative disorder named after German neurologist, Professor Nicholaus Friedreich.

Nicholaus Friedreich
Unknown author, CC BY 4.0, via Wikimedia Commons

Mnemonic: FRIEDREICH’S Ataxia

1. Foot deformity (progressive cavo-varus), Frataxin expression reduced

2. Recessive (autosomal), Repeat of trinucleotide GAA (chromosome 9)

3. Iron accumulation in mitochondria

4. Extensor plantar response

5. Dysarthria (within 5 years of onset), Dorsal column involvement, Diabetes mellitus

6. Reflexes (DTR) absent

7. Early onset (within 25 years of age)

8. Incoordination

9. Cerebellar and Corticospinal tract involvement

10. Hypertrophic cardiomyopathy

11. Scoliosis

12. Ataxia (progressive)

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