Diacerin is a DMOAD (Diseases Modifying Osteoarthritis Drug) –
D – Diarrhea (not recommended in >65 years – more vulnerable to diarrhea)
I – IL-1 Inhibition
A – Anthraquinone
C – Chondroprotective effects
E – Eczema
R – Rashes
I – Increase in hepatic enzymes (contraindicated in patients with history of liver diseases)
N – NSAID like efficacy after 1st month of treatment
a. Interosseous: Extend deeply, directly between two bones Radioscapholunate (RSL) aka Ligament of Testut (neurovascular conduit to SL ligament) Scapholunate (SL) and Lunotriquetral (UL) – volar, dorsal and proximal fibrocartilaginous membrane components Capitohamate (CH) b. Palmar-proximal V: Converge as an “upside-down V” from the radius/ulna to lunate Radio-luno-triquetral (RLT) –…
Anatomy of Vertebral Pedicle Width (narrowest transverse diameter): Narrowest at T4-T5 (4-5 mm) Above and below this level, the width gradually increases to almost double at T1 and T11 (8 mm) Narrowest for lumbar at L2 (two for tiny; 2 X 3 = 6 mm) Increases gradually to L5 (5…
Structure of Heme Heme is a ferro-proto-porphyrin. Heme = Protoporphyrin IX ring + Iron (Fe) in center Protoporphyrin IX = porphyrin with attachment to 4 Methyl, 2 Propionyl and 2 Vinyl groups. Porphyrin = Cyclic structure with 4 pyrrole rings Pyrrole rings are derived from Porphobilinogen (PBG) Hydroxymethylbilane = Linear…