PGMEE, MRCS, USMLE, MBBS, MD/MS
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Wound Healing : Stages
1. Haemostasis (immediate): In response to exposed collagen, platelets aggregate at the wound and degranulate, releasing inflammatory mediators. Clotting and complement cascades activated. Thrombus formation and reactive vasospasm achieve haemostasis. 2. Inflammation (0-3 days): Vasodilatation and increased capillary permeability allow inflammatory cells to enter wound, and cause swelling. Neutrophils amplify inflammatory response by release…
PGMEE, MRCS, USMLE, MBBS, MD/MS
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Somogyi effect and Dawn Phenomenon – Mnemonic
Both Somogyi effect and Dawn phenomenon are the cause of MORNING FASTING HYPERGLYCEMIA. Mnemonic: Somogyi = So Much InsulinDawn = Down Insulin a. Somogyi effect: Excess exogenous insulin → Middle night hypoglycemia → Release of counter-regulatory hormones → Rebound morning hyperglycemia b. Dawn effect: Normal release of morning hormones (growth…
PGMEE, MRCS, USMLE, MBBS, MD/MS
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Understanding Dexamethasone Suppression Test
The Dexamethasone Suppression Test (DST) is based on the principle of negative feedback exerted by steroids on pituitary gland’s ACTH secretion. Negative feedback with exogenous steroid works if the cause is excessive ACTH secretion from pituitary: 1. Cushing’s disease (pituitary ACTH dependent Cushing’s syndrome): Excessive ACTH secretion by pituitary adenoma…