Mnemonic: FAHeem TATtooes because of Histrionic Personality Disorder (HPD) Tyrosine is necessary for biosynthesis of catecholamines, thyroid hormones and melanin pigment. 1. Tyrosinemia type I (Tyrosinosis/Hepatorenal tyrosinemia): Enzyme defect: FAH (Fumaryl-acetoacetate hydroxylase) Last enzyme in the cycle Cabbage like odor Hepatocellular carcinoma Renal tubular acidosis Peripheral neuropathy 2. Tyrosinemia type II…
PGMEE, MRCS, USMLE, MBBS, MD/MS
Competitive, Non-competitive and Uncompetitive Inhibitors
Vmax is the maximum velocity, or how fast the enzyme can go at full ‘‘speed.’’ Vmax is reached when all of the enzyme is in the enzyme–substrate complex. Km is the substrate concentration at which v = 1/2 Vmax. Km approximately describes the affinity of the substrate for the enzyme….
PGMEE, MRCS, USMLE, MBBS, MD/MS
Beta-oxidation of Fatty Acids : Simplified
Fatty Acid Activation (Cytoplasm) Before undergoing oxidation, fatty acid must be activated first by conversion into Acyl-CoA by the action of Fatty Acyl-CoA synthase (thiokinase). ATP is converted to AMP (not ADP) – 2 ATP equivalent used Uses Mg2+ as cofactor, Co-ASH and ATP Sites of Beta-oxidation A. Mitochondria: Short/Medium…
PGMEE, MRCS, USMLE, MBBS, MD/MS
Fatty Acid Synthesis : Simplified
Enzymes: Fatty acid synthase (6 enzymes and 1 Acyl carrier protein molecule) Acetyl-CoA carboxylase (rate-limiting enzyme) Starting material: For palmitate synthesis: Acetyl-CoA For odd number carbon long chain fatty acid synthesis: Propionyl-CoA 2 Carbon donor: Malonyl-CoA (donates 2 C and 1 C is thrown out as CO2) Site: Cytosol Citrate…
PGMEE, MRCS, USMLE, MBBS, MD/MS
Structure of Fatty acids and Derivatives : Simplified
Structure Saturated fatty acid: Single bond (“S” for saturated and single bond) Unsaturated fatty acid: Double bond(s), i.e. “D” for Double bonds, Decreased melting temperature and Decreased atherosclerotic risk (by decreasing LDL) Trans-fatty acid: Unsaturated fatty acid which act like saturated fatty acid (hydrogenation of unsaturated fatty acid) Nomencleture: C…
PGMEE, MRCS, USMLE, MBBS, MD/MS
Orexigenic and Anti-orexigenic peptides : Mnemonic
Orexigenic (Appetite stimulant) peptides Mnemonic: When you see MANGOEs, you feel like eating. MCH (Melanocyte Conentrating Hormone) AGRP (Agouti Related Peptide) NPY (Neuropeptide Y), Noradrenaline GnRH, GABA, Galanin, Ghrelin Orexins A and B Endorphins, Endocannabinoids Anti-orexigenic (Appetite supressant) peptides Mnemonic: NO BLACk PIGS Neurotensin Oxytocin, Oxyntomodulin Bombesin Leptin Alpha-MSH (POMC derivative), Amylin,…
PGMEE, MRCS, USMLE, MBBS, MD/MS
Fetal Skull Dimensions : Mnemonic
Anteroposterior Diameters Mnemonic: Larger the alphabets, larger the diameter (V>F>B) Diameters with “sub” prefix are smaller than counterpart without it. mento-Vertical: 14 cm SUB-mento-Vertical: 11.5 cm occipito-Frontal: 11.5 cm SUB-occipito-Frontal: 10.5 cm sub-occipito-Bregmatic: 9.5 cm sub-mento-Bregmatic: 9.5 cm Transverse Diameters Mnemonic: MTP (Medical Termination of Pregnancy) in increasing order. bi-Mastoid:…
PGMEE, MRCS, USMLE, MBBS, MD/MS
Pelvic Dimensions : Mnemonics
Shapes of the female pelvis Mnemonic: GAP (In order of most common to the least common) Only pelvis with AP diameter > Transverse diameter is Anthropoid pelvis. Mnemonic: ANthrOPoid Android and Anthropoid (AN) pelvis are common causes of occipito-posterior (OP) presentation. In platypelloid pelvis (broad and flat): Sub-public angle: It…