Synonyms:
- Osteitis deformans
- Collage of matrix madness
Mnemonic: Sixteen “P”s
1. Paramyxovirus infection and inclusions in osteocalsts
2. Pain (most common symptom – localized fractures or nerve compressions)
3. Pelvis (most common site)
4. Polyostotic (more common; 85%)
5. Phases: Active (lytic, mixed, sclerotic) and Inactive
6. Plasma volume expansion due to AV shunting (high output cardiac failure)
7. Premalignant lesion (paget’s sarcoma in <1%)
8. Phosphorous and calcium normal
9. Phosphatase (ALP) elevated in blood (bone formation markers)
10. Proline (hydroxyproline), Peptides (N and C telopeptides), Pyridinoline (deoxypyridinoline) elevated in urine (bone resorption markers)
11. Pamidronate (bisPhosphonates) – 1st line drugs
12. PTH analogues (teriparatide) contraindicated (risk of secondary osteosarcoma)
13. Picture frame vertebra (pathognomic appearance in X-ray)
14. Pelvic brim sign (thickening of pelvic brim outlined by iliopectineal line)
15. Platybasia and basilar invagination
16. Pyre (candle flame or blade of grass) sign: lucent leading edge in a long bone seen during the lytic phase
He is the section editor of Orthopedics in Epomedicine. He searches for and share simpler ways to make complicated medical topics simple. He also loves writing poetry, listening and playing music. He is currently pursuing Fellowship in Hip, Pelvi-acetabulum and Arthroplasty at B&B Hospital.
Brilliant! covered almost all important points