Ollier’s disease
Maffucci syndrome
Concentric layers of Granuloma There are 4 concentric layers in a granuloma, however the clear distinction is difficult in reality due to overlapping. From inside to out: 1. Necrosis Caseating necrosis: Tuberculosis, Leprosy Coagulative necrosis: Buruli ulcer (M.ulcerans), Gumma containing central blood vessels (Syphilis) Fibrinoid necrosis: Aschoff bodies (Rheumatic granuloma),…
Lets work with some generalizations 1. X-linked dominant, mitochondrial and Y-linked conditions are rare. You need to remember them. 2. Usually inherited in autosomal dominant pattern are: Mostly mutations in non-enzymatic structural proteins (e.g. collagen, fibrillin, cytoskeletal proteins of RBC) or in membrane receptors (e.g. LDL receptor) Diseases due to diminished…
Introduction: Other facts: Clinical features: Diagnosis: Role of biopsy/tissue diagnosis in GIST (current consensus): Treatment: High risk features: Choices of surgery: Aim of surgery: Prognostication: Malignant potential Comments Mortality Benign Size: up to 2 cmMitosis: up to 5/50 hpf No tumor related mortality Probably benign Size: 2-5 cmMitosis: same as…