ANCA : Mnemonics

ANCA = Anti-Neutrophil Cytoplasmic Antibodies


1. “P” is not going with “P”
2. p-ANCA is positively charged and hence, attacks negatively charged MPO (free radicals)
3. c-ANCA (C is 3rd letter) attacks PR-3

  1. p-ANCA = perinuclear-ANCA against Myeloperoxidase (MPO)
  2. c-ANCA = cytoplasmic-ANCA against Proteinase-3 (PR-3)

ANCA positive conditions

1. c-ANCA:

Mnemonic: Common Wealth Games

  • Wegner’s Granulomatosis (Granulomatosis with polyangitis)

2. p-ANCA:

Most of other conditions are p-ANCA positive.

  • Eosinophilic granulomatosis with Polyangitis (Churg-Strauss syndrome)
  • Microscopic Polyangitis
  • GoodPasture syndrome
  • RPGN
  • Primary sclerosing cholangitis
  • Inflammatory bowel disease
  • Autoimmune hepatitis

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