t(8;14): Burkitt’s lymphoma t(14;18): Follicular lymphoma t(11;14): Mantle cell lymphoma t(11,18): Marginal zone lymphoma (MALT lymphoma) t(9;22): CML (Philadelphia chromosome), Bad prognosis ALL t(8;21): AML M2 t(15;17): AML M3 (Promyelocytic AML) t(X;18): Synovial cell sarcoma t(11;22): Ewing’s sarcoma t(12;21): Pre-B ALL (good prognosis ALL) t(4;11) and t(1;19): Bad prognosis ALL
Author: Epomedicine
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Cell-Cell or Interceullular Junctions
Junction Location Composition Function Remarks Tight junction (Zonula occludens) Epithelial cell-Epithelial cell Claudin and Occludin (attaches to cytoskeleton – actin filament) Prevents paracellular movement of solutes and diffusion Adherens junction (Zonula adherens) Epithelial cell-Epithelial cell E-cadherin (attaches to cytoskeleton – actin filament) Belt desmosome (Anchoring) Cadherins are Ca2+ depndend adhesion…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Which statistical test to use?
Steps: Types of data Mnemonic: NOIR Qualitative or Categorical data a. Nominal (relating to name): Groups e.g. gender (male/female), color (black/white), blood groups (A/B/AB/O), religions (hindu/muslim/christian) b. Ordinal (relating to order): Rank-ordered data but without meaningful difference; e.g. socio-economic status (low, middle and high), rank (1st, 2nd and 3rd)– without…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Why is hepatitis E dangerous during pregnancy?
Hepatitis E Virus (HEV) infection is usually a self-limiting disease with a low rate of fulminant hepatic failure but maternal hepatitis E during the third trimester of pregnancy is a cause of fulminant hepatic failure with a mortality rate of upto 20%. Severe liver injury due to HEV in pregnancy…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
National Immunization Schedule of Nepal (2024)
There should be at least 7 contacts of children (At birth, 6,10,14 weeks, 9, 12, 15 months) to health center to fully immunize as per national immunization programme of Nepal. Previously, 11 antigens were provided through national immunization program. Recently, rotavirus vaccine and fIPV (fractional IPV) has been added. Nepal is polio…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Parinaud Syndrome – Anatomical Basis
Synonyms: Dorsal midbrain sydnrome, Pretectal syndrome Main components of Parinaud syndrome: Vertical gaze palsy Convergence-retraction nystagmus Pupillary light-near dissociation Lid retraction (Collier’s sign) Anatomical basis of Parinaud syndrome: Site of lesion: Dorsal midbrain Close to cerebral aqueduct and pineal gland – hydrocephalus and pinealoma Arterial supply – posterior cerebral artery…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Personality Disorders – Mnemonic
If you are having a hard time remembering the clusters and which disorder falls into which cluster, this mnemonic will be helpful. Three clusters: A, B and C; remember as WWW – Weird, Wild and Worried, respectively. Cluster A – Weird (Genetic association with Schizophrenia) Accusatory: Paranoid (Suspicious) Aloof: Schizoid…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Simplified ICD-10 Diagnostic criteria for Schizophrenia
1. Duration: ≥1 months 2. ≥1 of Schneider’s 1st rank symptoms: Mnemonic: ABCDE a. Auditory hallucinations: Voices heard arguing (3rd person), Thought echo, Running commentary b. Bizzare delusions: Voices coming from some part of the body c. Control (Delusion of control): Somatic, Impulse, Volition, Affect (SIVA) d. Delusional perception: A non-hallucinated/true perception…