Types of Transplant Rejection Type Time Mechanism Pathology Hypersensitivity Management Host against Graft (Host vs Graft) Mnemonic: TIA Hyperacute Immediate (<5 days) Anti-donor antibodies in recipient Thrombosis and Obliteration of blood supply Type II UntreatablePrevent by cross-matchingRemove graft Acute (most common) < 6 months (most common in 1st month) Anti-donor…
Tag: Pathology
PGMEE, MRCS, USMLE, MBBS, MD/MS 
ANCA : Mnemonics
ANCA = Anti-Neutrophil Cytoplasmic Antibodies Types Mnemonics: 1. “P” is not going with “P”2. p-ANCA is positively charged and hence, attacks negatively charged MPO (free radicals)3. c-ANCA (C is 3rd letter) attacks PR-3 ANCA positive conditions 1. c-ANCA: Mnemonic: Common Wealth Games 2. p-ANCA: Most of other conditions are p-ANCA…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Adenoma-Carcinoma Sequence in Colorectal Cancer : Mnemonic
Adenoma-carcinoma sequence is a stepwise development of normal epithelium to carcinoma due to accumulation of mutations over a number of years leading to activation of oncogenes and loss of tumor suppressor genes. One of the pathways follows adenoma–carcinoma sequence, that is, normal → adenoma → carcinoma. The other is pertaining…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Lynch Syndrome (HNPCC) : Mnemonics
Inheritance: Autosomal Dominant (AD) Cause: Microsatellite instability (MLH1, MSH2 mismatch repair gene mutation) Types: Amsterdam II Criteria for Diagnosis Mnemonic: 3-2-1-0 rule Colorectal cancers: More likely to be mucinous and right-sided Treatment: Total colectomy with ilio-rectal anastomosis Annual screening: Age 25 onwards or beginning no later than 5 years before…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Pheochromocytoma : Mnemonics
Pheochromocytoma is a catecholamine-producing tumor arising from chromaffin cells of the sympathetic nervous system derived embryologically from the primitive neural crest cells. Sites: Clinical features Mnemonic: 5 H or 7 P’s 5 H 7 P Hypertension Paroxysmal rise in pressure (BP) Headache Pain (headache) Hyperhidrosis Perspiration (hyperhidrosis) Hyperglycemia Pallor Hypermetabolism…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Glucagonoma : 6 D’s
Glucagonoma is an alpha-cell tumor of pancreas. Mnemonic: 6 D’s 1. Diabetes 2. Dermatitis (Necrolytic migratory erythema) 3. Declining weight 4. Diarrhea 5. Deep vein thrombosis 6. Dilated cardiomyopathy
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Thyroid Tumors : Mnemonics
Papillary carcinoma Follicular carcinoma Medullary carcinoma Mnemonic: MENACED Anaplastic carcinoma
Case Reports 
A case of child with Mucopolysaccharidosis : Hunter Syndrome
1st Published in Pedchrome in January 1, 2015 Case Summary A 6-year-old patient was found to have course facial features and short stature. Parents have noticed a developmental stasis since 4-5 years of age. The weight was normal. There were no any chronic illness, any significant birth and postnatal history…