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Mnemonics, Simplified Concepts & Thoughts

Tay Sach’s Disease : Mnemonic

Epomedicine, Oct 31, 2024Oct 31, 2024

Last updated on October 31, 2024

Mnemonic: SACHS GO

1. Spots in macula (Cherry red spots)

2. Ashkenazic jews

3. CNS degeneration

4. Hexosaminidase A enzyme deficiency

5. Storage disorder

6. GM2 ganglioside accumulation

7. Onion skin appearance of lysosomes

HEXA gene 15q
United States, National Institutes for Health, Public domain, via Wikimedia Commons
HexA gene is located on 15q

Further reading:

Lysosomal Storage Disorders Made Easy
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PGMEE, MRCS, USMLE, MBBS, MD/MS Biochemistry

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Epomedicine. Tay Sach’s Disease : Mnemonic [Internet]. Epomedicine; 2024 Oct 31 [cited 2025 May 9]. Available from: https://epomedicine.com/medical-students/tay-sachs-disease-mnemonic/.

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