Mnemonic: SACHS GO
1. Spots in macula (Cherry red spots)
2. Ashkenazic jews
3. CNS degeneration
4. Hexosaminidase A enzyme deficiency
5. Storage disorder
6. GM2 ganglioside accumulation
7. Onion skin appearance of lysosomes
Further reading:
Synonym: Knee-locking mechanism Definition: During the final degrees of knee extension (last 20-30 degrees), an obligatory lateral rotation of the tibia occurs, i.e. non-voluntary coupled movement of knee extension and external rotation. Mechanism: External rotation of tibia with reference to the femur or Internal rotation of femur with reference to…
Origin: Neuroendocrine cells Location: Lungs, Bronchi, Trachea, Gastrointestinal tract Synthesize: Biogenic amines (mainly serotonin which is metabolied to 5-HIAA) 5 Manifestations Mnemonic: 5-HIAAS 1. Heart disease (2/3 patients) 2. Intestinal manifestations 3. Airway obstruction 4. Asthma 5. Skin manifestations Alternative mnemonic: CARCinoid Rule of 1/3 Surgery for appendiceal carcinoid tumor…
Nipah virus is closely related to, but distinct from Hendra virus. Family: Paramyxoviridae Genus: Henipavirus History: A Nipah epidemic of viral encephalitis, complicated by respiratory failure, occurred in Malaysia in 1998 and 1999, causing 265 infections and 105 fatalities (93% had occupational exposure to pigs). An associated outbreak among abbatoir…