Mnemonic: 2 out of ABCDEFG
1. Axillary or inguinal freckling
2. Bone lesions (sphenoid dysplasia, tibial pseudoarthrosis)
3. Cafe au lait macules/spots (>/= 6 in number; >/= 5 mm in prepubertal and >/= 15 mm in postpubertal)
4. Dermatologic neurofibroma
5. Eye hamartomas/Lisch nodules >/= 2
6. Family history (first degree relative)
7. Glioma of optic nerve
The diagnosis of NF1 requires atleast 2 of 7 NIH criteria.
a. SCF (Steel factor): Multipontent stem cells b. IL-3: Myeloid stem cells (“3” turned down looks like “m“) c. IL-7: Lymphoid stem cell (“L” turned up looks like “7“) d. GM-CSF (Granulocyte macrophage Colony stimulating factor): Myeloid lineage (Erythrocytes, Thrombocytes, Granulocytes and Monocytes) Pharmaceutical: Sargramostim e. G-CSF: Granulocytes (Neutrophil, Eosinophil,…
Synonyms: Dorsal midbrain sydnrome, Pretectal syndrome Main components of Parinaud syndrome: Vertical gaze palsy Convergence-retraction nystagmus Pupillary light-near dissociation Lid retraction (Collier’s sign) Anatomical basis of Parinaud syndrome: Site of lesion: Dorsal midbrain Close to cerebral aqueduct and pineal gland – hydrocephalus and pinealoma Arterial supply – posterior cerebral artery…
Heart Tube At the beginning of 4th week of development, heart is a continuous and valveless linear tube that resembles a chicken hung upside-down. It consists of 5 embryonic dilatation, that are destined to be the inflow and outflow tract and compartments of the hear without septum and valves. From cranial…