Mnemonic: 2 out of ABCDEFG
1. Axillary or inguinal freckling
2. Bone lesions (sphenoid dysplasia, tibial pseudoarthrosis)
3. Cafe au lait macules/spots (>/= 6 in number; >/= 5 mm in prepubertal and >/= 15 mm in postpubertal)
4. Dermatologic neurofibroma
5. Eye hamartomas/Lisch nodules >/= 2
6. Family history (first degree relative)
7. Glioma of optic nerve
The diagnosis of NF1 requires atleast 2 of 7 NIH criteria.
Cell Wall Synthesis Inhibitors A peptidoglycan monomer consists of 2 joined amino-sugars, N-acetyl glucosamine (NAG) and N-acetyle muramic acid (NAM), with a pentapeptide coming off of the NAM. So, a peptidoglycan monomer is a NAG-NAM-pentapeptide. These peptidoglycan monomers are synthesized in cytosol and transported across cytoplasmic membrane by Bactoprenols (BP)….
ANCA = Anti-Neutrophil Cytoplasmic Antibodies Types Mnemonics: 1. “P” is not going with “P”2. p-ANCA is positively charged and hence, attacks negatively charged MPO (free radicals)3. c-ANCA (C is 3rd letter) attacks PR-3 ANCA positive conditions 1. c-ANCA: Mnemonic: Common Wealth Games 2. p-ANCA: Most of other conditions are p-ANCA…
1. Haemostasis (immediate): In response to exposed collagen, platelets aggregate at the wound and degranulate, releasing inflammatory mediators. Clotting and complement cascades activated. Thrombus formation and reactive vasospasm achieve haemostasis. 2. Inflammation (0-3 days): Vasodilatation and increased capillary permeability allow inflammatory cells to enter wound, and cause swelling. Neutrophils amplify inflammatory response by release…