ANCA : Mnemonics

ANCA = Anti-Neutrophil Cytoplasmic Antibodies

Types

Mnemonics:
1. “P” is not going with “P”
2. p-ANCA is positively charged and hence, attacks negatively charged MPO (free radicals)
3. c-ANCA (C is 3rd letter) attacks PR-3

1. p-ANCA = perinuclear-ANCA against Myeloperoxidase (MPO)
2. c-ANCA = cytoplasmic-ANCA against Proteinase-3 (PR-3)

ANCA positive conditions

1. c-ANCA:

Mnemonic: Common Wealth Games

• Wegner’s Granulomatosis (Granulomatosis with polyangitis)

2. p-ANCA:

Most of other conditions are p-ANCA positive.

• Eosinophilic granulomatosis with Polyangitis (Churg-Strauss syndrome)
• Microscopic Polyangitis
• GoodPasture syndrome
• RPGN
• Primary sclerosing cholangitis
• Inflammatory bowel disease
• Autoimmune hepatitis