In medical schools, we learn many things without knowing the actual reason behind it. One of them is the pre-transfusion fever in a patient being planned for blood transfusion which is considered as a contraindication for it in many departments and health centers. So, the questions that came into my…
Tag: Pathology
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Wound Healing : Stages
1. Haemostasis (immediate): In response to exposed collagen, platelets aggregate at the wound and degranulate, releasing inflammatory mediators. Clotting and complement cascades activated. Thrombus formation and reactive vasospasm achieve haemostasis. 2. Inflammation (0-3 days): Vasodilatation and increased capillary permeability allow inflammatory cells to enter wound, and cause swelling. Neutrophils amplify inflammatory response by release…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Non-invasive Prenatal Screening
Quick review/Mnemonic: PAPP-A is decreased in all trisomies.Nuchal translucency is increased in all trisomies. Inhibin A is only increased in Down’s syndrome.Beta-HCG is increased in Down’s syndrome. All triple test results decreased in Edward syndrome. Only AFP is increased in NTDs and abdominal wall defects. Acetylcholinesterase level increased in Amniotic…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Revised Jone’s Criteria – Mnemonic
Remember SPACE LEAF for Revised Jone’s Criteria (2015). Major criteria Mnemonic: SPACE Subcutaneous nodules Pancarditis Arthritis (Polyarthritis; for moderate to high-risk population – monoarthritis also qualifies) Chorea Erythema marginatum Minor criteria Mnemonic: LEAF Long PR interval ESR ≥ 60mm/hr (or ≥ 30mm/hr in moderate to high-risk population) and CRP ≥…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Bartter, Gitelmann and Liddle syndrome
The order of the nephron defects in Bartter, Gitelmann and Liddle syndrome follows alphabetical order. Bartter: Thick ascending LOHGitelmann: Distal tubuleLiddle: Collecting duct a. Bartter syndrome: Thick ascending Loop of Henle (LOH) Defect in Na-2K-Cl transporter (like loop diuretics) NaCl wasting, Hypercalciuria and mild hypomagnesemia Mnemonic: Loop diuretics lose calcium…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
HLA association mnemonics
The genes that encode HLA (Human Leukocyte Antigen) are on chromosome 6. MHC class Type Location Function I HLA-A, -B, -C All cells Recognized by CD8+ lymphocytes II HLA-DP, -DQ, -DR Antigen presenting cells Recognized by CD4+ lymphocytes III Complement components Plasma Chemotaxis, opsonization, lysis of bacteria and cells The…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Differential Diagnoses of Bone Tumors : Mnemonic Approach
Lytic and Sclerotic Bone Lesions Mnemonic for Solitary lytic lesions: FEGNOMASHIC Fibrous dysplasia Enchondroma Eosinophilic granuloma Giant cell tumor Nonossifying fibroma Osteoblastoma, Osteosarcoma (telangiectatic) Metastases Myeloma Aneursymal bone cyst Simple bone cyst Hyperparathyroidism (brown tumor) Infection Chondroblastoma Chondromyxoid fibroma Mnemonic for Multiple lytic lesions: FEMHI Fibrous dysplasia Eosinophilic granuloma/Enchondroma Metastasis/Mutiple…
PGMEE, MRCS, USMLE, MBBS, MD/MS 
Oncogenic Translocations to remember
t(8;14): Burkitt’s lymphoma t(14;18): Follicular lymphoma t(11;14): Mantle cell lymphoma t(11,18): Marginal zone lymphoma (MALT lymphoma) t(9;22): CML (Philadelphia chromosome), Bad prognosis ALL t(8;21): AML M2 t(15;17): AML M3 (Promyelocytic AML) t(X;18): Synovial cell sarcoma t(11;22): Ewing’s sarcoma t(12;21): Pre-B ALL (good prognosis ALL) t(4;11) and t(1;19): Bad prognosis ALL