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Mnemonics, Simplified Concepts & Thoughts

Lynch Syndrome (HNPCC) : Mnemonics

Epomedicine, Jul 21, 2023Jul 30, 2023

Last updated on July 30, 2023

Inheritance: Autosomal Dominant (AD)

Cause: Microsatellite instability (MLH1, MSH2 mismatch repair gene mutation)

Types:

  1. Lynch 1 syndrome: Early onset colorectal cancers
  2. Lynch 2 syndrome: Colorectal cancer + Extraintestinal malignancies (Mnemonic: CEO)
    • Colorectal cancer
    • Endometrial cancer
    • Ovarian cancer
lynch syndrome

Amsterdam II Criteria for Diagnosis

Mnemonic: 3-2-1-0 rule

  1. 3 or more relatives with pathologically verified Lynch cancers
  2. 2 or more successive generations
  3. 1 or more case diagnosed before 50 years age
  4. 0 FAP (Familial Adenomatous Polyposis excluded)

Colorectal cancers: More likely to be mucinous and right-sided

Treatment: Total colectomy with ilio-rectal anastomosis

Annual screening: Age 25 onwards or beginning no later than 5 years before the lowest age of onset in family

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PGMEE, MRCS, USMLE, MBBS, MD/MS Gastrointestinal systemGeneral SurgeryObGynOncologyPathology

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  1. Kelvin says:
    Jul 22, 2023 at 12:17 pm

    Awesome. Your mnemonics is always in point thank you . God bless you for teaching.

    Reply

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Epomedicine. Lynch Syndrome (HNPCC) : Mnemonics [Internet]. Epomedicine; 2023 Jul 21 [cited 2025 May 30]. Available from: https://epomedicine.com/medical-students/lynch-syndrome-hnpcc-mnemonics/.

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