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Mnemonics, Simplified Concepts & Thoughts

Is Fever a contraindication for Blood transfusion?

Dr. Sulabh Kumar Shrestha, MS Orthopedics, Apr 15, 2021Apr 15, 2021

Last updated on April 15, 2021

In medical schools, we learn many things without knowing the actual reason behind it. One of them is the pre-transfusion fever in a patient being planned for blood transfusion which is considered as a contraindication for it in many departments and health centers. So, the questions that came into my mind were:

  1. What makes fever a contraindication for blood transfusion?
  2. Is pre-transfusion fever actually a contraindication for blood transfusion or just a misunderstanding?
blood transfusion
BruceBlaus. When using this image in external sources it can be cited as:Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014”. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436., CC BY 3.0, via Wikimedia Commons

These are what my search yielded:

Receiving and Administering A Blood Component (Simon Goodwin and Ruth O’Donnell) 1https://www.transfusionguidelines.org/document-library/documents/receiving-and-administering-a-blood-component-workbook/download-file/rtc-sec_admin_wkbk_08_03_04.pdf

“Having a fever is not a contraindication to a patient receiving a blood transfusion; however, if the fever is new, it is advised that medical advice should be sought before the transfusion commences in case treating the fever is deemed to be a higher priority than the transfusion.“

Blood Bank, Department of Pathology, Michigan Medicine 2https://www.pathology.med.umich.edu/blood-bank/transfusion-faq

“With physician approval, a transfusion may be administered to a febrile patient. However, if a patient is febrile, consideration should be given to postponement of the blood transfusion, since the fever may mask the development of a febrile reaction to the blood component itself.“

Bloody Easy 4 – A Guide to Transfusion Medicine (4th Edition) 3http://policyandorders.cw.bc.ca/resource-gallery/Documents/Transfusion%20Medicine/Bloody%20Easy%204.pdf

“Fever is not a contraindication to commencing a blood transfusion!”

There weren’t any sources that mentioned fever before the transfusion as the contraindication to transfusion itself. It seems that the only concern is that it may mask the fever that develops during transfusion which may be due to non-hemolytic or hemolytic reactions to blood products or contaminate blood products.

If you have a new insight into the issue, please comment below for discussion.

dr. sulabh kumar shrestha
Dr. Sulabh Kumar Shrestha, MS Orthopedics

He is the section editor of Orthopedics in Epomedicine. He searches for and share simpler ways to make complicated medical topics simple. He also loves writing poetry, listening and playing music.

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  1. Robin says:
    Sep 8, 2022 at 2:41 am

    Hi.
    Do you know where the myth of not transfusing if the patient has a fever comes from?

    Reply

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Shrestha SK. Is Fever a contraindication for Blood transfusion? [Internet]. Epomedicine; 2021 Apr 15 [cited 2025 May 9]. Available from: https://epomedicine.com/blog/fever-contraindication-blood-transfusion/.

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