Risk factors
Mnemonic: ABCD
- Alcohol abuse
- BMI <18.5 kg/sq.meter
- Chemotherapy
- Drugs (insulin) and Diuretics
Pathophysiology
Mnemonic: PPM
Malnourished (depleted intracellular Phosphate, Potassium, Magnesium) → Refeeding → Increased glucose load → Insulin spikes → Drives PPM into cells → Hypophosphatemia (major abnormality), hypokalemia, hypomagnesemia
Prevention
If patient hasn’t not eaten for >5 days, aim to refeed at <50% energy and protein levels.
Monitor and aggresively supplement PPM.