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lhermittes sign

Lhermitte’s Sign

Epomedicine, Jul 11, 2016Jul 11, 2016

Last updated on July 11, 2016

Synonym: Lhermitte’s phenomenon, Barber chair phenomenon

Definition of Lhermitte’s Sign

Lhermitte’s sign (pronounced Ler-meets) is an electric shock-like sensations, spreading along the spine in a cervico-caudal direction and into the arms and legs felt upon active or passive flexion of the neck.

Reverse Lhermitte’s Sign is defined when symptoms are induced by neck extension, not flexion.

Pathophysiology of Lhermitte’s Sign

Because flexion of the neck causes the dysaesthetic symptoms, it has been suggested that an increased mechanical sensitivity of these damaged myelinated axons in the dorsal cloumn of the spinal cord causes an abnormal origin or transmission of sensory information. 1Lhermitte’s sign in cavernous angioma of the cervical spinal cord. Murphy D.K., Gutrecht J.A. (1998)  Journal of neurology, neurosurgery, and psychiatry,  65  (6) , pp. 954-955.

Neck flexion causes a mechanical stimulation of the damaged myelinated axons by lengthening and deforming the affected area of the cervical spinal cord.

Reverse Lhermitte’s phenomenon is said to be induced by extrinsic compression of the cervical cord and neck collar immobilization.

Causes of Lhermitte’s Sign

  1. Multiple sclerosis (in 1/3rd patients)
  2. Vitamin B12 deficiency – Subacute Combined Degeneration of spinal cord (in 1/4th patients)
  3. Cervical spondylosis
  4. Cervical spinal cord tumors
  5. Radiation myelopathy
  6. Head injuries
  7. Arnold-Chiari malformation
  8. High-dose chemotherapy
  9. Cisplatin neurotoxicity
  10. Nitric oxide neurotoxicity
  11. Arachnoiditis 2Lhermitte’s sign: Review with special emphasis in oncology practice Gemici, Cengiz; Critical Reviews in Oncology / Hematology , Volume 74 , Issue 2 , 79 – 86

Eliciting Lhermitte’s Sign

lhermittes sign

One patient described it as follows: “When I bent my head, I felt a violent shock in my neck and a pain like an electric current running through my whole body, from the neck down the vertebral column into the feet”. 38. Frederiks JAM. Lhermitte’s sign. In: Koehler PJ, Bruyn GW, Pearce JMS, editors. Neurological eponyms. Oxford: Oxford University Press; 2000. p. 106-10.

Maneuver: Forward flexion of head (actively or passively)

Outcome: Electric sensation spreading from spine into extremities (symmetrical or asymmetrical)

Lhermitte’s sign were elicited also by:

  1. Neck rotation, arm abduction, coughing 4The Sensitive Nervous System By David S. Butler – Neurodynamic testing for Spine and lower limb
  2. Yawning 5Sagiuchi T, Tachibana S, Sato K, et al. Lhermitte sign during yawning associated with congenital partial aplasia of the posterior arch of the atlas. AJNR Am J Neuroradiol2006;27:258–60.

Video for Lhermitte’s Sign

Accuracy of Lhermitte’s Sign

Two studies found that the sensitivity of Lhermitt’s sign is markedly poor, ranging from 3 to 17%. One of these studies also found that it presented good specificity (97%) for nonspecific compressive myelopathy. 6Teive Hélio Afonso Ghizoni, Haratz Salo, Zavala Jorge, Munhoz Renato Puppi, Scola Rosana Hermínia, Werneck Lineu César. Lhermitte’s sign and vitamin B12 deficiency: case report. Sao Paulo Med. J.  [Internet]. 2009  [cited  2016  July  10] ;  127( 3 ): 171-173. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802009000300011&lng=en.  http://dx.doi.org/10.1590/S1516-31802009000300011.

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Epomedicine. Lhermitte’s Sign [Internet]. Epomedicine; 2016 Jul 11 [cited 2025 May 24]. Available from: https://epomedicine.com/clinical-medicine/lhermittes-sign/.

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